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Lexogen at the Vienna BioCenter

Lexogen – A company at the forefront of the fastest developing technology

About Lexogen​


Established in 2007, Lexogen is a global leading company in transcriptomics, next-generation sequencing, RNA analysis, and bioinformatics. Lexogen is the leader in 3’ mRNA sequencing, a technology proven for its efficiency, its robustness, and its sensitivity.

Lexogen’s portfolio includes innovative kits developed and produced in Vienna, Austria, for true single-cell as well as bulk RNA sequencing, RNA extraction, ribosomal RNA depletion, spike-in RNA variant controls, and nascent RNA labeling for transcriptome-wide analysis of RNA kinetics. Lexogen also provides first-class, fully integrated, customizable NGS services, from experimental design consulting to sample processing and tailored bioinformatics analysis and reporting.

Lexogen is a privately held company headquartered in Vienna, Austria, with a subsidiary in New Hampshire, USA.

Our vision (We want to become…)

The RNA Experts
The best company to work for and with.

Our mission

Empower our customers with innovative top quality RNA analysis solutions & support, in order to improve health and well-being for everyone and our planet.

Lexogen style (our business way)

Lexogen imperatives (our mindset and values)​

We trust and support each other, listen, be open to new ideas/thoughts and are non-judgemental. Managers empower their team and delegate decisions. 

We valorize ideas and initiatives. 

We set an error-friendly atmosphere: no blame, no finger pointing, a constant learning and improvement spirit.

We simplify things in such a way that they are easy to use and to understand without being an expert or a skilled person. 

We communicate simply, in a short and effective way (clear and obvious). We refrain from using technical words when it is not necessary.  

We remain simple, humble as a mark of respect for others, to show our willingness to listen to others, accept their point of view, and acknowledge their feelings.

We are impartial and create an environment of security, freedom, and harmony.

We act with integrity, do the right thing and follow the rules and regulations but also our chart, whether it benefits us or not as an individual. Since one cannot have integrity without being honest, this implies also a strong honesty, being sincere and refusing deceit, fraud or malevolence.

We are transparent i.e. open, honest and straightforward, to build trust and clarity, to ease communication and interactions, to create a safe environment free from fear, and to support innovation by encouraging openness about achievements and mistakes. 

We act with respect and humanity in what we do and with whom we interact, in order to protect their dignity.

We care of and serve others (our colleagues, our customers…) through a stewardship attitude.

We believe that together, as a team, we are stronger.

We share our passion and our enthusiasm.

We come as we are and we enjoy what we do.

We celebrate each success, yours or ours, big or small, and also lessons learnt from errors.

Inclusivity and equity​

Lexogen strives to cultivate an inclusive and accessible workplace where all people feel comfortable being themselves in a safe and supportive environment (a zero tolerance policy applies to disrespect of others).

We believe diversity of background, personality, ability, experience, and thought makes for a better workplace, better decision-making, and more innovation. We focus on cultivating a sense of belonging and an environment where everyone can thrive.

We believe the more our team represents the world around us, the more innovative and performant we are; and the better we are at reaching our vision, because WE, all the team members, are Lexogen.

LGBTQIΠ+, BAME, Dys-X, B-out, disabled, Gen Z, Millenials and seniors… be welcome to join us and help us building Lexogen!

What is so intriguing about the transcriptome?​


Grasshoppers are gentle creatures with brilliant green color and mild temper who mostly enjoy their solitude and live in good harmony with neighbors in the environment. But the other brood, the locust, forms huge swarms, darkens the sky, and greedily devours whatever is on their way, sometimes scaring people and frowning the eyebrows of farmers.

What is fascinating is that these two creatures are actually one species, and they share exactly the same genetic information stored in the form of DNA. Under a certain condition, the grasshoppers turn their color into light brown, their legs become short and spiky, and the wings grow to adapt to cover the long distance of swarm travel, becoming one of the most greedy and aggressive populations on earth.


You don’t need to go far away into the jungle of Africa to see such examples, because even in the human body we can observe similar things, like cancer cells which originate from healthy cells with identical genetic information in DNA. What contributes the most to this Dr. Jekyll and Mr. Hyde process is the RNA, or transcription of genomes, which is called transcriptome.

The transcriptome has long been considered as a key for answering many of the questions in genetics, biology and medicine, extending far beyond central dogma. However its applications have been limited due to technical difficulties, and not much was known about it until recent advancements in the Next Generation Sequencing (NGS) technology. Thanks to NGS, we expect to have a much larger amount of RNA data than what we have accumulated so far in the history of biology.



December 2023

Release of Kangooroo – Lexogen data analysis platform
Release of QuantSeq 3’ mRNA-Seq V2 Library Prep Kit REV

November 2023

Release of LUTHOR High-Definition Single-Cell 3′ mRNA-Seq Library Prep Kit

July 2023

Release of PCR Add-on and Reamplification Kit V2

May 2023

Release of RNA/DNA Defender Solution

October 2022

Release of QuantSeq with UDI V2 library preparation kits

September 2022

Release of RiboCop for Yeast

April 2022

Release of CORALL RNA-Seq V2 Kits

December 2018

Upgrade TeloPrime Full-Length cDNA Amplification Kit V2

May 2018

Release of UMI Second Strand Synthesis Module for QuantSeq FWD (Illumina, Read 1)

Upgrade of i5 Unique Dual Indexing Add-on Kit for QuantSeq/SENSE (5001-5096)

July 2018

We are providing Services for Small RNA-Seq, QuantSeq for SLAMseq RNA, and SPLIT RNA Extraction

February 2017

Release of QuantSeq 3’ mRNA-Seq Library Prep Kit (FWD) HT for Illumina

March 2017

Release of RNA-Seq service for generation of QuantSeq 3’ mRNA-Seq libraries, multiplexed sequencing, and data analysis

June 2017

Release of SIRV Set 2 (Iso Mix E0) and 3 (Iso Mix E0 / ERCC)

August 2017

Release of Small RNA-Seq Library Prep Kit

September 2017

Release of SLAMseq Metabolic RNA-Seq Kit

October 2017

Release of SLAMdunk SLAMdunk data analysis for SLAMseq integrated on the BlueBee® platform

November 2017

Data Analysis pipeline for QuantSeq 3’ Library Prep is implemented in Partek® Flow® software

December 2017

Release of new Globin Block Modules for QuantSeq Kits

June 2016

CLC Plug-in “Mix-Square Transcript Quantification”

August 2016

Upgrade RiboCop rRNA Depletion Kit V1.2 (Human/Mouse/Rat)   

Special User Guide for SENSE Total RNA-Seq for FFPE samples

October 2016

Integrated QuantSeq 3’mRNA-Seq Data Analysis Pipeline on the BlueBee Genomics Platform

Upgrade QuantSeq-Flex Targeted RNA-Seq Library Prep Kit V2   

December 2016

Release of the i5 Dual Indexing Add-on Kit for QuantSeq/SENSE

March 2014

Release of QuantSeq 3’ mRNA-Seq Library Prep Kit

The QuantSeq kit was developed in collaboration with a research institute to meet the demand for a cost-efficient RNA-Seq library preparation method for gene expression analysis by only counting the 3’ end of transcripts.

April 2014

Foundation of Lexogen, Inc. in the US

To be closer to our customers in the USA, enabling overnight delivery on most orders, a subsidiary, Lexogen, Inc.,  was established in New Hampshire in April 2014 as a distribution center.

June 2014

Release of SENSE Total RNA-Seq Library Prep Kit

September 2014

Release TeloPrime Full-Length cDNA Amplification Kit

October 2014

Upgrade SENSE mRNA-Seq Library Prep Kit V2

February 2013

Release of SENSE mRNA-Seq Library Prep Kit

Lexogen has developed a fast, easy and fragmentation-free RNA-Seq library prep kit based on its proprietary strand-displacement stop/ligation technology, yielding libraries with an exceptional strand-specificity.

August 2013

Release of SPLIT RNA Extraction Kit

Lexogen has, since the start of the company, put a lot of effort into optimizing extraction protocols for the isolation of high quality RNA without any genomic DNA contamination. After the protocol was successfully shared with some customers, efforts were made to put all the know how into a kit.

September 2013

Innovation and employment subsidy by WAFF

The WAFF (Vienna Employment Promotion Fund) supports small and medium-sized companies in Vienna with the implementation of innovation projects and funded Lexogen for the development of the Mix2 software and the SIRVs.

January 2012

1 year FFG grant and innovation voucher

June 2011

Relocation to the Vienna BioCenter

Due to the rapid growth and expansion of the company, Lexogen decided to move to a new place at the Vienna BioCenter in Vienna, Austria, which is the current location of Lexogen’s headquarter, R&D unit and kit production. The company occupies about 850m of area on two floors; more than quadruple the space of the previous location.


October 2011

Seed-Financing by AWS

The Austria Wirtschaftsservice Gesellschaft mbH (aws) is the Austrian federal promotional bank. It assists in the foundation and development of innovative companies in the high-tech field and Lexogen acquired seed-financing by the agency.

3 years FFG grant and innovation voucher

The company received funding by the Austrian Research Promotion Agency (FFG) for the development of the SQUARE technology. The FFG is the national funding institution for applied research and development in Austria.

August 2007

Foundation of Lexogen GmbH by Alexander Seitz

The company was founded in August 2007 by Dr. Alexander Seitz with the support of INiTS (Innovation into Business) incubator, having the first employee starting work in October 2007. Lexogen´s first facility was located in a campus in Southern Vienna (Liesing), Austria, where the company stayed until May 2011.


“We are using QuantSeq as our go-to method in the lab for transcriptome analyses. The fast and easy work-flow, reduced sequencing costs and easy data analysis make it a very useful and reliable tool in our daily work. Therefore, we also utilized QuantSeq in our work involving the clonal isolation tool CaTCH to characterize the transcriptomes of therapy-resistant and therapy-naïve clonal cancer cell pairs.”

Christian Umkehrer, PhD, Scientist at Research Institute of Molecular Pathology, Austria

“We have successfully used the CORALL kit in our latest project to generate high quality sequencing libraries from low input material. With its fast and clear protocol we were able to generate the libraries in less than one day. We will surely use the CORALL kit again and recommend it for whole transcriptome analysis.”

Jason Sims, PostDoc, Schlögelhofer Group, Department of Chromosome Biology, Max Perutz Labs, Vienna

“We have used the LUTHOR 3’ mRNA-Seq Library Prep Kit to profile single cells, which we FACS sorted before. The quality of the data is impressive: we detect high numbers of transcripts per cell by moderate sequencing depth. This allows us to comprehensively identify cell state and subtle cell state changes in the analyzed samples. For these aims, the 3’ mRNA-Seq library generated with the LUTHOR Kit has advantages over full-length cDNA approaches we have used previously. I can recommend LUTHOR for single-cell RNA-Seq analysis.”

Merrit Romeike, PhD Student, Buecker Group, Max Perutz Labs Vienna, Austria

“We have been using QuantSeq for over 5 years to profile samples that we have found previously difficult to target, such as formalin fixed, paraffin embedded (FFPE) samples. We have found that QuantSeq allows good reproducibility, low sample input requirements and rapid turnaround, allowing us to make the most of these precious samples.”

Andrew Beggs, Professor of Cancer Genetics & Surgery, Institute of Cancer and Genomic Sciences University of Birmingham, UK

“Throughout my career, leading genomic projects and departments, I have always been a fan of Lexogen chemistry. When I finally decided to co-found a genomics company, I was delighted to hear that Lexogen had a services arm, and signed up immediately. We work with extremely challenging samples, from biobanked FFPEs to micro-organ samples. At every step Lexogen has worked closely with us, even helping to optimise our protocols, to ensure the best possible results.”

Quin Wills, Co-founder and CSO, Ochre Bio

“The TraPR kit was very good at efficiently and specifically isolating small RNAs. I used it on Drosophila melanogaster tissues for differential analysis using qRT-PCR. I definitely recommend it.”

Elisa Bernard, PhD student, Newbury group, Brighton and Sussex Medical School, UK

“Transcriptional profiling is one of our key approaches to study and understand the molecular mechanism of action of cancer drugs. We have made excellent experiences with the CORALL kit both in terms of experimental feasibility but also data quality. Through integration with synthetic spike-ins SIRVs, It was particularly helpful when testing drugs that affect overall transcriptional output and thus cause a global decrease in mRNA levels.”

Georg Winter, PhD, Principal Investigator, CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences

“I was able to isolate more RNA, and of significantly better quality, using the SPLIT RNA kit than I have been able to with any other RNA extraction protocol I so far when extracting RNA from P. infestans sporangia and zoospores.”

Sean Patev, Department of Plant Pathology and Plant-Microbe Biology, Cornell University, USA

“We used the new CORALL kit for performing transcriptome-analysis of CRISPR-modified cells in order to understand the consequences of deregulated epigenetic modifiers. In our hands the kit performance was highly satisfying in terms of data-quality and reproducibility across biological replicates. It furthermore convinced us with the ease of use, clarity of instructions, details in the manual, and handling of reagents.”

Max Koeppel, Head of Functional Tumor Genomics Group at Leibniz-Institute DSMZ, Germany

“We have been extensively using the FWD QuantSeq protocol for over a year on a wide variety of sample inputs and levels of quality. It has become our go-to protocol for all transcriptome exploration projects. We like the ease of the workflow and the consistency of the results combined with significantly lower library construction costs compared to Illumina, Clontech and NuGEN. Most impressive are the results for samples with low RINs. We have a recent example of one project that included both high quality and very degraded RNA samples with RINs as low as 1. We used RNA inputs between 10 and 40 ng and sequenced to the depth of about 13 M reads/sample. Resulting gene detection rates were 13 K in the lowest RIN samples. The average across the entire set was 14.2 K. We are now evaluating QuantSeq on a set of RNA samples originated from FFPE material and looking forward to switching over from the Illumina Access protocol.”

Zarema Arbieva, Director, Core Genomics Facility, University of Illinois at Chicago, USA

“We have extensively tested Lexogen’s RiboCop META rRNA depletion kit on bacteria for transcriptomics. Due to a research focus in infection biology at our university, we are working on RNA sequencing projects with various types of bacteria. The RiboCop META is a versatile tool with very good depletion results for all types of bacteria tested so far. Therefore, we would like to continue to use it for future transcriptome profiling projects.”

Tobias Heckel, Head Core Unit Systems Medicine (NGS & Bioinformatics), University of Würzburg, Germany

“To compare gene expression measures between 3’-RNA-seq and RNA-seq technologies, we used data from a subset of 20 samples that were previously used in a RNA-seq study of feed efficiency. The correlation of the log10(fold-change) for gene expression (high- vs. low-feed efficiency birds) between these two methods was 0.90. In conclusion, 3’-RNA-seq is a cost effective method amenable to global gene expression studies at population-level, e.g., expression QTL (eQTL) mapping. Also, it allows for accurate detection of the 3’-end of transcripts, enabling verification of the current gene model annotations and global characterization of alternative polyadenylation.”

Behnam Abasht, Assistant Professor, University of Delaware, USA

“Using the QuantSeq 3′ mRNA-Seq library prep kits, we were able to multiplex >40 samples per sequencing lane and obtain between 2 to 5 million reads per sample. This enabled us to analyze numerous different strains with various exosome and roadblocking factors inactivated, showing that inactivating roadblocks shifted the window of NNS termination downstream.”

Kevin Roy, Postdoctoral Scholar, Lars Steinmetz Lab, Department of Genetics Stanford University School of Medicine, USA

“With Lexogen Poly(A) Selection kit I was able to isolate reasonable amount of polyadenylated RNA with no trace of rRNA contamination. I see great advantages of this kit in clear-cut protocol and quite low starting concentration of total RNA that you can easily scale-up based on chosen downstream application. The other thing that should be appreciated is Lexogen customer service that provides you with very high level of support.”

Květoslava Brožinová, Research Technician, Research Group: ERA Chair – RNA and Immunity, CEITEC, Brno, Czech Republic

“We have used the QuantSeq 3′ mRNA-Seq library prep kit for generating over 2000 libraries. Preparing 96 samples at a time is easy and can be done in one day. We multiplexed 48 samples on a HiSeq lane and thereby obtained 3 million reads per sample on average. Using this shallow sequencing approach, we were highly impressed by the quality of the data and robustness of the method.”

Bianca Gapp, PhD student, Ludwig Institute for Cancer Research, Oxford, UK

“We have successfully used the Lexogen QuantSeq FWD kit for the preparation of RNAseq libraries over the last year. The kit provides us with a highly cost effective and reliable, fast solution to generate RNAseq libraries that we subsequently use to assess gene expression levels and most importantly to rapidly compile and assess alternative cleavage and polyadenylation profiles. QuantSeq is a cornerstone for our RNAseq based research, in particular as multiplexing allows us to combine it with cost effective sequencing on the Ion Torrent platform.”

André Furger, Associate Professor, Chromosomal and RNA Biology, Department of Biochemistry, University of Oxford, UK

“Using the Lexogen strand-specific RNAseq kit enabled us to generate multiple libraries for massively parallel sequencing in a matter of a few days. The protocol is very detailed, concise and straightforward, and consistently results in high quality material for Illumina sequencing. Analysis of the RNA libraries found good coverage of transcripts across an expression range of five logs. Additionally, we observed enrichment in the expression of expected transcripts under our experimental conditions, with an average CV of less than 5% in biological replicates within the top half of expressed transcripts. The strand specificity of the libraries was excellent, at around an estimated 99.9%, based on the distribution of strandedness for annotated genes. From this analysis we conclude that some 20% of transcripts are directly associated with significant anti-sense transcription, providing a rich source of interesting biological challenges.”

Iryna Charapitsa, Institute of Molecular Biology, Mainz, Germany


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