RNA/DNA Defender Solution

Protect fragile RNA in fresh tissue and cell samples
Safely pause your workflow until more convenient to continue
No need for snap freezing or dry ice shipments

RNA/DNA Defender Solution

Preserving RNA in tissues and cultured cells is crucial for maintaining the gene expression profile. RNA/DNA Defender is a storage solution that stabilizes and protects RNA and DNA molecules after tissue excision and cell culture harvesting. It eliminates the need to process samples immediately or snap-freeze them in liquid nitrogen. Samples can be stored temporarily at ambient temperature without compromising RNA quality until processing is more convenient.

Convenient sample storage

Tissues submerged in RNA/DNA Defender Solution and cells resuspended in RNA/DNA Defender Solution can be stored for

one day at 37 °C
one week at room temperature
one month at +4 °C
up to one year at -20 °C

RNA/DNA Defender stabilizes RNA in tissues

Storage of tissue pieces in RNA/DNA Defender Solution stabilizes contained RNA even at temperature of 37 °C or over longer periods of time at -20 °C (Fig. 1).

Figure 1 | RNA/DNA Defender Solution stabilizes RNA in tissue samples. Mouse liver tissue was either fresh frozen or stored in RNA/DNA Defender Solution or a competitor RNA stabilization solution for one day at 37 °C or for over one year at -20 °C. After storage RNA was extracted using SPLIT RNA Extraction kit and analyzed on Fragment Analyzer.

Step1:

Total time for Step:

Hands-on time for Step :

Extract desired tissue / harvest cultured cells and transfer into a fresh tube. RNA/DNA Defender
Solution rapidly permeates tissues and cells, and stabilizes contained RNA and DNA molecules.

RNA/DNA Defender Solution enables temporary storage of the specimen at temperatures where normally RNA degradation would occur.

Extract RNA and/or DNA at your convenience using your method of choice.

Frequently Asked Questions

Access our frequently asked question (FAQ) resources via the buttons below.

Please also check our General Guidelines and FAQ resources!

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User Guide – release 23.05.2023

Safety Data Sheet

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If you need more information about our products, please contact us through support@lexogen.com or directly under +43 1 345 1212-41.

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RNA/DNA Defender Solution
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