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RiboCop rRNA Depletion Kits

Select and Deplete.

Sequence what matters most!

Ribosomal RNA Depletion

(noun) /rɑ́jbəwsə́wməl RNA dɪplɪ́jʃən/

Total RNA is comprised of large amounts of ribosomal RNA (rRNA) which can make up between ~80 – 98 % of all RNA molecules in a sample. Ribosomal RNA depletion removes these undesired transcripts to access transcripts of interest. Ultimately, rRNA depletion enables detection of all types of non-ribosomal RNAs, including coding mRNAs and non-coding transcripts such as snoRNAs, snRNAs, and lncRNAs. Thereby, ribosomal depletion affords an undisturbed view of an organism’s complete transcriptome.

RiboCop rRNA Depletion Kits

Total RNA is comprised of large amounts of undesired ribosomal RNA (rRNA). RiboCop enables very efficient removal of rRNA. Besides ribosomal RNA, RiboCop can also deplete globin mRNA, which makes up 30 – 80 % of all mRNA in mammalian blood. Thus, RiboCop focuses sequencing reads on RNA of interest while maintaining unbiased expression profiles.

New! RiboCop rRNA Depletion for Plants affords an unbiased view of the complete plant transcriptome and allows analysis of coding, non-coding, and non-polyadenylated RNAs.

RiboCop Kits are available for:


Sequence what matters most! RiboCop rRNA Depletion is a well-established, enzyme-free, and automation-friendly rRNA depletion kit for various species, including human, mouse, rat and bacterial samples. RiboCop offers exceptional performance on low input samples, down to 1 ng starting amount and is the ideal solution for total RNA-Seq analysis on degraded and FFPE samples.


Preserve your RNA!

RiboCop’s enzyme-free workflow preserves RNA integrity and is ideal for challenging downstream applications.

Ideal for challenging samples

The enzyme-free protocol is the ideal choice for depletion of degraded RNA including formalin-fixed, paraffin-embedded (FFPE) samples.

Maximize unique sequencing reads

Sequence what matters with RiboCop by removing highly abundant undesired transcripts from human, mouse, rat, bacterial and yeast samples.

Avoid depletion bias

Sophisticated probe design allows efficient removal of undesired transcripts while maintaining unbiased transcriptome profiles.

Unlock low input samples

RiboCop supports the widest RNA input range (1 ng – 1000 ng) and is suitable for efficient depletion of samples down to 1 ng total RNA input.

Process Blood Samples with Ease

RiboCop for Human/Mouse/Rat plus Globin simultaneously depletes rRNA and globin mRNA, providing a highly convenient workflow for blood samples and significantly frees up sequencing space for RNAs of interest.

Applications for RiboCop rRNA Depletion



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