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Webinar: Why are Vaccines Effective in Some Individuals but Not in Others?

Webinar: Why are Vaccines Effective in Some Individuals but Not in Others?

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Abstract

Transcriptomic profiling has been used to identify key immunological determinants that underpin vaccine response in individuals. Most critically, it is now known that the state of the innate and adaptive immune system even before the introduction of the vaccine has a strong association with the efficacy of the vaccine. These findings could inform future studies into SARS-CoV-2 vaccination.

In this webinar, Pieter Meysman, post-doctoral researcher at the University of Antwerp, will outline the use of transcriptomic profiling before and after vaccination to explore the differences between poor and good vaccine responders. Meysman and colleagues studied the effect of the common hepatitis B vaccine and measles, mumps, and rubella (MMR) vaccination on the transcriptomic profile from blood. This webinar will further explore how such data can be used to predict vaccine response based on baseline gene expression measurements. Meysman will cover the different aspects underlying the design and application of these studies, from how to define responder types to the data processing required to generate reliable predictors.

Speaker’s biography

Pieter-Meysman_Webinar

Pieter Meysman, PhD
Post-Doctoral Researcher in Biological Data Mining
University of Antwerp

Pieter Meysman obtained his doctorate from the KU Leuven in 2012 in bioscience engineering with research on unraveling the transcriptional regulatory mechanisms through computational biology. He currently works on novel ways to process the growing diversity of biomedical data at the University of Antwerp. Since 2015, he has been the computational lead of the AUDACIS consortium, a multi-disciplinary group specializing in usingimmunoinformatics and immunosequencing techniques for clinical applications in vaccinology, infectious diseases, tumor immunology, and auto-immunity.

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