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Is LUTHOR HD the right solution for your RNA research? Let’s find out!
High-Definition single-cell RNA sequencing
/ haɪ ˌdɛfɪˈnɪʃᵊn ˈsɪŋɡᵊl sɛl ɑːr-ɛn-eɪ ˈsiːkwənsɪŋ/
A single cell typically expresses thousands of different genes at the same time. Most of these genes are represented only in a few copies. High-Definition single-cell RNA sequencing (HD scRNA-Seq) collects any mRNA present in the sample, even those lowly expressed transcripts (less than 10 copies). HD scRNA-Seq, therefore, provides a comprehensive overview of the full transcriptomic status in each cell.
HD scRNA-Seq applications
High-Definition single-cell RNA sequencing works best with ultra-low initial inputs (as low as 10 pg RNA). By seeing more genes than classical bulk scRNA-Seq methods, it expands transcriptomic analysis into new scientific applications.
- High-definition single-cell differential gene expression analysis
- Detailed characterization of cell subpopulations after larger, less sensitive screenings (bulk scRNA-Seq)
- Rare cell RNA analysis (e.g., circulating tumor cells (CTCs) or innate lymphoid cells (ILCs))
- Subcellular (cytoplasm, organelle) RNA analysis
- Single nucleus RNA-Seq
Meet the LUTHOR family
LUTHOR solutions, developed by Lexogen, equip researchers with new tools to dive into single-cell RNA sequencing with unprecedented sensitivity. Lexogen’s LUTHOR portfolio currently includes:
- LUTHOR High-Definition Single-Cell 3’ mRNA-Seq Library Prep Kit
- LUTHOR High-Definition Pool Single-Cell 3’ mRNA-Seq Library Prep Kit
- LUTHOR single cell dispenser (with a unique validated workflow, from cell to library)
And there is more to come!
Discover the LUTHOR family in this short video.
Benefits
LUTHOR HD reaction allows to amplify minuscule amounts of RNA material and to obtain a full understanding of each cell’s gene expression status.
Unmatched sensitivity
UMI included
Direct RNA amplification
Compatible with "less-than-a-cell" inputs
Not sure if LUTHOR HD is the right solution for your RNA research?
Try the LUTHOR HD Configurator and find out in less than 2 minutes!
