This webinar will discuss how homologous recombination at the highly conserved rDNA locus in Arabidopsis thaliana is tightly regulated during meiosis, a fundamental process and key to plant breeding and food security.
The rDNA locus encodes the ribosomal RNA (rRNA) genes, which constitute the catalytic core of the ribosomes – complex and abundant molecular machines responsible for translating the genetic information from mRNAs into proteins in all living cells. By combining cytological and next generation sequencing approaches, Jason Sims and colleagues at the Max Perutz Labs found that the rDNA locus is embedded within a unique meiotic-refractory environment that is tightly controlled throughout meiotic progression.
In his presentation Dr.Sims will outline:
- How he and his colleagues revealed the presence of tissue-specific ribosomal variants in Arabidopsis.
- How the variants are differentially transcribed at different meiotic stages.
These findings support the concept of specialized ribosome subpopulations with distinct rRNA composition that are assembled in a tissue-specific manner and may exert regulatory functions based on their rRNA composition.